Application of aptamer-functionalized nanomaterials in molecular imaging of tumors

Abstract Cancer is one of the most important causes human death. Early diagnosis and treatment can make patients live longer. Therefore, there an urgent need to develop early accurate method for tumors. Molecular imaging technology be used qualitative quantitative analyses at cellular molecular levels, which provides a new In recent years, various nanomaterials with unique properties have been tumor imaging. Meanwhile, aptamers are becoming indispensable element in design functional because their small size, high stability, convenient modification, especially giving ability recognize specific targets. aptamer-functionalized (AFNs) provide unprecedented opportunities field diagnosis. Here we focus on latest development AFNs First, introduce characteristics advantages common aptamer-modified organic inorganic nanomaterials. Then, applications fluorescence imaging, computed tomography, magnetic resonance radionuclide ultrasound photoacoustic multimode fusion discussed. Finally, some perspectives challenges that arisen from this promising area.